Annual report pursuant to Section 13 and 15(d)

Equity Incentive Plan (Details)

v3.22.2
Equity Incentive Plan (Details) - $ / shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Equity Incentive Plan      
Number of Options, Outstanding at beginning of year 246,893 174,175  
Number of Options, Granted 345,865 93,165  
Number of Options, Expired (32,544) (17,114)  
Number of Options, Forfeited (44,292) (3,333)  
Number of Options, Outstanding at end of year 515,922 246,893 174,175
Number of Options, Exercisable at end of year 201,653 142,061  
Number of Options, Vested and expected to vest at end of year 515,922 246,893  
Weighted- Average Exercise Price, Outstanding at beginning of year $ 20.90 $ 27.42  
Weighted- Average Exercise Price, Granted 4.11 6.31  
Weighted- Average Exercise Price, Expired 25.86 10.59  
Weighted- Average Exercise Price, Forfeited 6.49 7.20  
Weighted- Average Exercise Price, Outstanding at end of year 10.43 20.90 $ 27.42
Weighted- Average Exercise Price, Exercisable at end of year 22.00 31.58  
Weighted- Average Exercise Price, Vested and expected to vest at end of year $ 10.43 $ 20.90  
Weighted-Average Remaining Contractual Life (In Years), Outstanding 8 years 3 months 18 days 7 years 2 months 12 days 6 years 2 months 19 days
Weighted-Average Remaining Contractual Life (In Years), Exercisable at end of year 6 years 4 months 13 days 5 years 10 months 6 days  
Weighted-Average Remaining Contractual Life (In Years), Vested and expected to vest at end of year 8 years 3 months 18 days 7 years 2 months 12 days